Browsing by Author "Akanbi, Musa Oyebowale"

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    Evaluation of agronomic and drought response traits in two cultivars of soybean for cultivation in the Transkei region of the Eastern Cape
    (University of Western Cape, 2020) Akanbi, Musa Oyebowale; Ludidi, Ndiko
    Drought is a major stress that affects the productivity of plants across the globe. The consequences of drought are posed to continue reducing agricultural productivity as world climate changes. This makes it imperative to improve tolerance of staple food crops to drought. Under drought stress, reactive oxygen species (ROS) accumulate, which may lead to oxidative damage of DNA, proteins and lipids.
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    Evaluation of selected carotenoids of Lycopersicon esculentum variants as therapeutic targets for 'Alzheimer's disease: an in silico approach BMC Molecular and Cell Biology
    (Springer, 2021-10) Bakare, Olalekan; Oluwaseun, Fadaka Adewale; Akanbi, Musa Oyebowale
    The seriousness and menace of the worldwide weight of 'Alzheimer's disease have been related to a few factors, which incorporate antioxidant system depletion, mutation of proteins, and high expression of cholinesterases due to ageing, environmental influence, diet, infectious agents, and hormonal imbalance. Overexpression of cholinesterases has been emphatically connected to 'Alzheimer's disease because of the unreasonable hydrolysis of acetylcholine and butyrylcholine. Certain plant phytochemicals, for example, beta-carotenoids, lutein, neoxanthin, and viola-xanthine from Lycopersicon esculentum Mill. Var. esculentum (ESC) and Lycopersicon esculentum Mill. Var. cerasiforme (CER) has been utilized altogether as a therapeutic candidate for the treatment of 'Alzheimer's disease. Therefore, this research sought to investigate the drug-likeness of the individual carotenoids as detailed for cholinesterase inhibition in the treatment of 'Alzheimer's disease. Four potential cholinesterase inhibitors from ESC and CER were retrieved from the PubChem database. Investigation of their drug-likeness, toxicity prediction, molecular docking, and dynamic simulations were carried out using Molinspiration, PreADMET V.2.0, Patchdock server, and Schrodinger Maestro software respectively. Neoxanthin was ranked the safest with a greater tendency to inhibit the cholinesterases with high binding affinity. In addition, its stability after simulation in a mimicked biological environment suggests its relevance as a potential drug candidate for the treatment of 'Alzheimer's disease through the inhibition of cholinesterases.