Browsing by Author "Adam, Razia Z"

Now showing 1 - 2 of 2
  • No Thumbnail Available
    Item
    A comparison of conventional root canal sealers with ones That use green synthesized nanoparticles for antimicrobial activity: protocol for a systematic review
    (JMIR Publications Inc., 2024) Mohamed, Abubaker; Ismail, Enas; Adam, Razia Z
    Background: Root canal failure and secondary endodontic infection are frequent clinical scenarios in dentistry. The main microorganisms implicated in root canal therapy failure are persistent Enterococcus faecalis, Candida albicans, and Staphylococcus aureus. To combat the impact of disease resistance, scientists are concentrating on alternative antimicrobial root canal sealers. Nanomaterials are a recent development in endodontic materials that exhibit great antimicrobial properties, making them an ideal material choice for root canal sealers. Objective: This systematic review aims to compare the antimicrobial properties of conventional root canal sealers to those incorporating green synthesized nanoparticles between 2010 and 2024. Methods: A well-constructed protocol was established and registered with PROSPERO (CRD42021286373). Ethics approval was obtained from the Biomedical Research and Ethics Committee from the University of the Western Cape (UWC; BM22/1/4). PRISMA-P (Preferred Reporting Items for Systematic Review and Meta-Analysis Protocols) reporting guidelines were followed. The included criteria demonstrate the green synthesized nanoparticles studies where the nanoparticles (NPs) are incorporated in root canal sealers. MeSH (Medical Subject Headings) terms were used for the search strategy of the systematic electronic databases for articles published in English between 2010 and 2024. The selected databases included Scopus, PubMed, Web of Science, Science Direct, EBSCOhost, SpringerLink, and Wiley Online. A quality assessment tool for laboratory studies will be used to critically appraise the included studies. If applicable, statistical measures (mean, SD, etc) will be used for data analysis and presentation of the results. Results: The protocol is registered with PROSPERO. A preliminary search was conducted using a determined search strategy across 8 electronic databases, and the review is now complete. Conclusions: It is anticipated that the results of this systematic review may reveal the increased interest and application for nanoparticle-enhanced root canal sealers. This will aid in the future development of root canal sealants and mitigate the risk of endodontic failure.
  • Thumbnail Image
    Item
    Antifungal and cytotoxic potential of green synthesized silver nanoparticles
    (University of Western Cape, 2021) Klein, Widadh; Adam, Razia Z
    The rate at which the population is ageing is much faster than in the past. An increase in age results in an increase in oral diseases. One of the most common types of oral diseases in the elderly are fungal infections caused by Candida albicans. It has been noted that drug resistance to fungal pathogens is developing into a serious threat to public health and healthcare systems worldwide. This has consequently led to the need to develop effective and innocuous treatment modalities. The purpose of this study was to explore the antimicrobial and cytotoxic potential of silver nanoparticles (AgNPs) synthesised from Berzelia lanuginose, Helichrysum cymosum, and Searsia crenata.