Magister Scientiae - MSc (Pharmaceutical Chemistry)

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https://hdl.handle.net/10566/14970

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Browsing by Author "Dube, Admire"

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    Evaluation of the effect of polyethylene glycol incorporation on the performance of poly(lactic-co-glycolic acid) nanoparticles
    (University of the Western Cape, 2016) Samkange, Tendai; Dube, Admire
    Nanoparticle drug delivery is challenged by the binding of proteins in blood which result in their rapid removal from the circulatory system. Nanoparticles engineered to delay protein binding have shown to have extended circulatory times. One such engineering technique is PEGylation, which is the coating of nanoparticles with polyethylene glycol (PEG). PEG shields the nanoparticle from adhesive interactions with proteins. However, the optimal PEG content required to impart this "stealth" property onto poly(lactic-co-glycolic acid) (PLGA) nanoparticles, is unknown. Moreover, the effect of PEGylation on drug release has not been thoroughly investigated.
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    Post-market assessment of the quality of first line regimen fixed-dose combination antiretrovirals in South Africa
    (University of the Western Cape, 2017) Suleiman, Reem Abdallah S.; Ward, Kim; Dube, Admire
    The rapid increase in access to new antiretrovirals (ARVs) worldwide and, especially in sub-Saharan Africa, coupled with the well-documented problem of poor quality ARVs in developing countries has underscored the need for quality assessment of these medicines. South Africa has the worst human immunodeficiency virus (HIV) epidemic profile in the world; consequently, it has rolled out the world's largest antiretroviral ARV programme. With increasing market penetration of generic medicine in South Africa and especially ARVs, there is a call for stringent quality control mechanisms following the marketing approval (post-market quality control) of these medications. Unfortunately, evidence suggests that the World Health Organisation (WHO) recommendations for this aspect of quality assurance is not met by most Medicine Regulatory Authorities. In South Africa and many other countries this is attributed to a lack of physical and financial resources to enforce effective post-marketing surveillance (PMS) of all pharmaceuticals available in the country.
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    Synthesis and characterisation of biomimetic immunostimulatory lipid-polymer hybrid nanoparticles
    (University of the Western Cape, 2022) Irabin, Aime Fabius; Dube, Admire
    Tuberculosis (TB), caused by Mycobacterium tuberculosis (M. tuberculosis), remains a fatal infectious disease and one of the top ten leading causes of mortality, particularly in developing countries. Current drug therapy for TB is challenged by the poor physiochemical properties of the antibiotics used. These properties impact their bioavailability, toxicity, and treatment duration, thereby negatively impacting patient adherence. These factors also contribute to the emergence of the difficult to treat multi-drug resistant strains of M. tuberculosis. Recently, immunotherapy has emerged as a promising alternative treatment modality for TB.