The global management of diabetes mellitus (DM) involves the administration of recommended
anti-diabetic drugs in addition to a non-sedentary lifestyle upon diagnosis. Despite the
success recorded from these synthetic drugs, the traditional method of treatment using medicinal
plants is increasingly accepted by the locals due to its low cost and the perceived no side effects.
Helichrysum species are used in folk medicine and are documented for the treatment of DM in different
regions of the world. This study reviews Helichrysum species and its compounds’ activities in
the management of DM.