Magister Scientiae - MSc (Microbiology)

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https://hdl.handle.net/10566/14797

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Browsing by Author "Faculty of Science"

Now showing 1 - 5 of 5
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    Differentials and disparities in the costs of major hospital procedures in South Africa: A structural analysis from the perspective of the supply side
    (University of the Western Cape, 2007) De Koker, Louise; Gabriel, Tali; Faculty of Science
    The aim of this study was to examine the extent to which providers' practices affect the cost of hospital procedures incurred by patients. The spsecific objective was to explore the magnitude of variations and statistically establish the significance of relationships between admission/specialist costs incurred by patients for four major procedures and the hospital group, geographical location, employer group and demmographic realted risk profiles. The study contributes to a better understanding of the way in which managed care companies could channel beneficiaries of medical schemes to efficient providers.
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    Differentiation between Quinolone Resistant and Sensitive Isolates of Campylobacter jejuni by a Multiplex PCR Assay
    (University of the Western Cape, 2006) Ebrahim, Nazneen; Gouws, Pieter A; Dept. of Microbiology; Faculty of Science
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    Functional analysis of the mouse RBBP6 gene using Interference RNA
    (University of the Western Cape, 2007) Pretorius, Ashley; Jasper, D.; Rees, G.; Faculty of Science
    The aim of this thesis was to investigate the cellular role of the mouse RBBP6 gene using the interference RNA (RNAi) gene targeting technology and also to understand the relevance of two promoters for the RBBP6 gene.
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    An in vitro study on the immunotoxicity of South African beer
    (University of the Western Cape, 2008) Neethling, Michelle; Pool, Edmund J.; Faculty of Science
    Traditionally brewed beers are of cultural and economic importance to many African nations. The presence of mycotoxins in African beer is a topic that needs to be addressed, since most African countries have a climate of high humidity and temperature that favours the growth of moulds. Mycotoxins challenge not only the health of animals and humans, but also the economy, especially in underdeveloped countries where contamination is most likely. Literature proves that mycotoxins depict various effects on the immune system including immunotoxicity. Beer analysis is therefore of utmost importance in order to evaluate organoleptic characteristics, quality, nutritional value as well as safety. The aims of this study involve the analysis and comparison of traditional and commercial beer in terms of physical characteristics, mycotoxin concentrations as well as effects on specific immune pathway biomarkers in order to elucidate possible immunotoxicity.
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    Purification and characterisation of plasmodium falciparum Hypoxanthine phosphoribosyltransferase
    (University of the Western Cape, 2007) Murungi, Edwin Kimathi; McIntosh, David B.; Sewell, Trevor; Faculty of Science
    Malaria remains the most important parasitic disease worldwide. It is estimated that over 500 million infections and more that 2.7 million deaths arising from malaria occur each year. Most (90%) of the infections occur in Africa with the most affected groups being children of less than five years of age and women. this dire situation is exacerbated by the emrggence of drug resistant strains of Plasmodium falciparum. The work reported in this thesis focuses on improving the purification of PfHPRT by investigating the characteristics of anion exchange DE-52 chromatography (the first stage of purification), developing an HPLC gel filtration method for examining the quaternary structure of the protein and possible end stage purification, and initialcrystalization trials. a homology model of the open, unligaded PfHPRT is constructed using the atoomic structures of human, T.ccruz and STryphimurium HPRT as templates.