Exosomes form tunneling nanotubes (TUNTs) in the blood-brain barrier: A nano-anatomical perspective of barrier genesis

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dc.contributor.authorMentor, Shireen
dc.contributor.authorFisher, David
dc.date.accessioned2022-10-18T08:08:23Z
dc.date.available2022-10-18T08:08:23Z
dc.date.issued2022
dc.description.abstractThe blood-brain barrier (BBB) is a robust interface between the blood and the central nervous system. Barrier type endothelium is able to limit paracellular (PC) movement, relegating molecular flux to the transendothelial pathways of brain endothelial cells (BECs). It is, therefore, apparent that any leakage via the PC shunts would effectively nullify the regulation of molecular flux across the transcellular pathways. The application of higher-resolution scanning electron microscopy (HR-SEM) illuminates the heterogenous, morphological profile that exists on the surface of BEC membranes and the relationship between these ultrastructures during the molecular construction of the PC space between adjacent BECs. In this study developing BEC monolayers were grown on mixed, cellulose esters insert membranes in a bicameral system.en_US
dc.identifier.citationMentor, S., & Fisher, D. (2022). Exosomes form tunneling nanotubes (TUNTs) in the blood-brain barrier: A nano-anatomical perspective of barrier genesis. Frontiers in Molecular Neuroscience, 15, 938315. https://doi.org/10.3389/fnmol.2022.938315en_US
dc.identifier.issn1662-5099
dc.identifier.urihttps://doi.org/10.3389/fnmol.2022.938315
dc.identifier.urihttp://hdl.handle.net/10566/8062
dc.language.isoenen_US
dc.publisherFrontiers Mediaen_US
dc.subjectNanotubesen_US
dc.subjectNanovesiclesen_US
dc.subjectExosomesen_US
dc.subjectBioscienceen_US
dc.subjectBiologyen_US
dc.titleExosomes form tunneling nanotubes (TUNTs) in the blood-brain barrier: A nano-anatomical perspective of barrier genesisen_US
dc.typeArticleen_US

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