Synthesis of 4-oxatricyclo[5.2.1.02,6]dec-8-ene-3,5-dione derivatives as lead scaffolds for neuroprotective agents

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dc.contributor.authorEgunlusi, A.O.
dc.contributor.authorMalan, S.F.
dc.contributor.authorJoubert, J.
dc.date.accessioned2021-09-07T20:37:23Z
dc.date.available2021-09-07T20:37:23Z
dc.date.issued2020
dc.description.abstractNeurodegenerative disorders are characterised by progressive loss of neuronal functions. Of the proposed mechanisms, excitotoxicity, mediated by prolonged glutamate activation and calcium overload, is prominent. NGP1-01, a polycyclic cage amine, and tricyclo[6.2.1.02,7]undec-9-ene-3,6-dione have been shown to display calcium-modulating properties. In this study, we synthesised structurally-related 4-oxatricyclo[5.2.1.02,6]dec-8-ene-3,5-dione as the base scaffold, and incorporated various functional moieties through aminolysis, to afford a series of imide derivatives. All final compounds were obtained in yields between 47-97% and their structures were confirmed by NMR, IR and MS. These structurally-related derivatives could potentially act as neuroprotective agents. Additionally, their synthetic versatilities could make them precursors, as lead compounds, to potential pharmacologically-active agents.en_US
dc.identifier.citationEgunlusi, Ayodeji & Malan, Sarel & Joubert, Jacques. (2020). Synthesis of 4-oxatricyclo[5.2.1.02,6]dec-8-ene-3,5-dione derivatives as lead scaffolds for neuroprotective agents. 10.24820/ark.5550190.p011.302.en_US
dc.identifier.issn1551-7012
dc.identifier.urihttp://hdl.handle.net/10566/6624
dc.language.isoenen_US
dc.publisherARKAT USAen_US
dc.subject4-Oxatricyclo[5.2.1.02,6]dec-8-ene-3,5-dioneen_US
dc.subjectCycloaddition reactionsen_US
dc.subjectAminolysisen_US
dc.subjectNorbornenesen_US
dc.subjectNorbornene scaffoldsen_US
dc.subjectNeurodegenerative disordersen_US
dc.titleSynthesis of 4-oxatricyclo[5.2.1.02,6]dec-8-ene-3,5-dione derivatives as lead scaffolds for neuroprotective agentsen_US
dc.typeArticleen_US

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