Understanding the epidemiology, pathophysiology, diagnosis and management of SARS-CoV-2

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dc.contributor.authorSibuyi, Nicole Remaliah Samantha
dc.contributor.authorFadaka, Adewale Oluwaseun
dc.contributor.authorAdewale, Olusola Bolaji
dc.date.accessioned2021-01-08T07:32:40Z
dc.date.available2021-01-08T07:32:40Z
dc.date.issued2020
dc.description.abstractThe emergence of coronavirus disease 2019 (COVID-19) in December 2019 has resulted in over 20 million cases and 741,808 deaths globally, affecting more than 200 countries. COVID-19 was declared a pandemic on 11 March 2020 by the World Health Organization. The disease is caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). There is limited information on COVID-19, and treatment has so far focused on supportive care and use of repurposed drugs. COVID-19 can be transmitted via person-to-person contact through droplet spread. Some of the recommended precautionary measures to reduce the rate of disease spread include social distancing, good hygiene practices, and avoidance of crowded areas. These measures are effective because the droplets are heavy and can only travel approximately 1 meter in the air, settling quickly on fixed surfaces. Promising strategies to combat SARS-CoV-2 include discovery of therapeutic targets/drugs and vaccines. In this review, we summarize the epidemiology, pathophysiology, and diagnosis of COVID-19. We also address the mechanisms of action of approved repurposed drugs for therapeutic management of the disease.en_US
dc.identifier.citationSibuyi, N. R. S. et al. (2020). Understanding the epidemiology, pathophysiology, diagnosis and management of SARS-CoV-2. Journal of International Medical Research, 48(8)en_US
dc.identifier.issn1473-2300
dc.identifier.uri10.1177/0300060520949077
dc.identifier.urihttp://hdl.handle.net/10566/5615
dc.language.isoenen_US
dc.publisherSAGEen_US
dc.subject2019-nCoVen_US
dc.subjectACE-2en_US
dc.subjectCoronavirusen_US
dc.subjectRepurposed drugsen_US
dc.subjectSARS-CoV-2en_US
dc.titleUnderstanding the epidemiology, pathophysiology, diagnosis and management of SARS-CoV-2en_US
dc.typeArticleen_US

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