The Coronavirus Nucleocapsid is a Multifunctional Protein

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Date

2014

Journal Title

Journal ISSN

Volume Title

Publisher

MDPI

Abstract

The coronavirus nucleocapsid (N) is a structural protein that forms complexes with genomic RNA, interacts with the viral membrane protein during virion assembly and plays a critical role in enhancing the efficiency of virus transcription and assembly. Recent studies have confirmed that N is a multifunctional protein. The aim of this review is to highlight the properties and functions of the N protein, with specific reference to (i) the topology; (ii) the intracellular localization and (iii) the functions of the protein.

Description

Keywords

Nucleocapsid protein, Coronavirus assembly, Coronavirus N, Intracellular localization, Protein topology

Citation

McBride, R.; Van Zyl, M.; Fielding, BC. (2014). The coronavirus nucleocapsid is a multifunctional protein. Viruses, 6 (8): 2991-3018