Genomic association of single nucleotide polymorphisms with blood pressure response to hydrochlorothiazide among south african adults with hypertension

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dc.contributor.authorMasilela, Charity Mandisa
dc.contributor.authorPearce, Brendon
dc.contributor.authorOngole, Joven Jebio
dc.date.accessioned2021-01-04T09:29:48Z
dc.date.available2021-01-04T09:29:48Z
dc.date.issued2020
dc.description.abstract: This study described single nucleotide polymorphisms (SNPs) in hydrochlorothiazideassociated genes and further assessed their correlation with blood pressure control among South African adults living with hypertension. A total of 291 participants belonging to the Nguni tribes of South Africa on treatment for hypertension were recruited. Nineteen SNPs in hydrochlorothiazide pharmacogenes were selected and genotyped using MassArray. Uncontrolled hypertension was defined as blood pressure ≥140/90 mmHg. The association between genotypes, alleles and blood pressure response to treatment was determined by conducting multivariate logistic regression model analysis. The majority of the study participants were female (73.19%), Xhosa (54.98%) and had blood pressure ≥140/90 mmHg (68.73%). Seventeen SNPs were observed among the Xhosa tribe, and two (rs2070744 and rs7297610) were detected among Swati and Zulu participants.en_US
dc.identifier.citationMasilela, C. M. (2020). Genomic association of single nucleotide polymorphisms with blood pressure response to hydrochlorothiazide among south african adults with hypertension. Journal of Personalized Medicine 10(4),267, 1-17en_US
dc.identifier.issn2075-4426
dc.identifier.uri10.3390/jpm10040267
dc.identifier.urihttp://hdl.handle.net/10566/5531
dc.language.isoenen_US
dc.publisherMDPIen_US
dc.subjectUncontrolled hypertensionen_US
dc.subjectHydrochlorothiazideen_US
dc.subjectSingle nucleotide polymorphismsen_US
dc.subjectSouth Africaen_US
dc.subjectPharmacogenomicsen_US
dc.titleGenomic association of single nucleotide polymorphisms with blood pressure response to hydrochlorothiazide among south african adults with hypertensionen_US
dc.typeArticleen_US

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