Corrigendum: Immunological changes during space travel: A ground-based evaluation of the impact of neutron dose rate on plasma cytokine levels in human whole blood cultures

dc.contributor.authorFisher, Randall
dc.contributor.authorBaselet, Bjorn
dc.contributor.authorRahiman, Farzana
dc.date.accessioned2021-10-15T12:03:33Z
dc.date.available2021-10-15T12:03:33Z
dc.date.issued2021
dc.description.abstractA better understanding of the combined impact of different space stressors on human health is urgently warranted, considering the upcoming long-duration missions beyond lower Earth orbit. Therefore, a growing number of particle accelerator facilities implement ground-based set-ups to study the effect of simulated space radiation with simulated psychological or physical stressors. The immune system is highly sensitive to these types of stressors and limited information is currently available on the impact of the complex space radiation environment on the astronauts’ immune function. This pilot study presents a first step in the implementation of a ground-based set-up with neutron irradiation, which is considered to be an important secondary component in space radiation fields. The effect of dose rate on immune alterations was studied using the in vitro cytokine release assay. Whole blood samples (n = 8) were exposed to 0.125 or 1 Gy of neutron irradiation (fluence-weighted average energy: 29.8 MeV) at a lower dose rate (LDR) of 0.015 Gy/min and a higher dose rate (HDR) of 0.400 Gy/min. Immediately post-irradiation, blood samples were stimulated with lipopolysaccharide (LPS), heat-killed Listeria monocytogenes (HKLM) or lectin pokeweed mitogen (PWM), and incubated for 24 h.en_US
dc.identifier.citationFisher, R. et al. (2021). Corrigendum: Immunological changes during space travel: A ground-based evaluation of the impact of neutron dose rate on plasma cytokine levels in human whole blood cultures. Frontiers in Physics, 9,677808. https://doi.org/10.3389/fphy.2021.677808en_US
dc.identifier.issn2296-424X
dc.identifier.uri10.3389/fphy.2021.677808
dc.identifier.urihttp://hdl.handle.net/10566/6918
dc.language.isoenen_US
dc.publisherFrontiers Mediaen_US
dc.subjectRadiation in spaceen_US
dc.subjectImmune systemen_US
dc.subjectSpace radiobiologyen_US
dc.subjectNeutron radiationen_US
dc.subjectAstronaut healthen_US
dc.titleCorrigendum: Immunological changes during space travel: A ground-based evaluation of the impact of neutron dose rate on plasma cytokine levels in human whole blood culturesen_US
dc.typeArticleen_US

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