The effects of Elytropappus rhinocerotis Cass and Pelargonium triste (L.) L'Hèrit on animal health and metabolism
| dc.contributor.advisor | Johnson, Quinton | |
| dc.contributor.advisor | Weitz, Frans M. | |
| dc.contributor.author | Duarte, Nazeema | |
| dc.date.accessioned | 2023-06-09T11:24:55Z | |
| dc.date.accessioned | 2024-11-04T13:15:07Z | |
| dc.date.available | 2023-06-09T11:24:55Z | |
| dc.date.available | 2024-11-04T13:15:07Z | |
| dc.date.issued | 2003 | |
| dc.description | Magister Scientiae (Medical Bioscience) - MSc(MBS) | en_US |
| dc.description.abstract | Many South Africans use cultural traditions and practices in the management of their health. Elytropappus rhinocerotis is an important medicinal plant, which is widely distributed in regions of South Africa. The objective of this study was to evaluate the anti-microbial characteristics of Elytropappus rhinocerotis extracts and to assess its effects on animal and metabolism. Elemental analyses were done on the plant and soil samples to determine the concentrations of selected elements within the plant. The leaves were sectioned using freeze-microtomy. Elytropappus rhinocerotic was screened using a MeOH extract and the disc diffusion method against Staphylococcus aureus (ATCC2gzl3), Mycobacterium smegmatis, Pseudomonas aeruginosa (ATCC27853) and dandida albicans (ATCC1023I). The positive control for the bacteria was Ciprofloxacin and Amphotericin B for the fungal yeast. Elytropappus rhinocerotic aqueous extract was administered to female mice (NMRI strain), which were divided into two groups of 10 each. The mice were given lgllO0mykddz1 of the plant extract for a period of 6 weeks. Various metabolic parameters were assessed over time and included the mice mass, stool production and selected elemental analyses, and water and food consumption. A variety of blood parameters and selected tissue samples were analysed after the animals were sacrificed. There was no significant difference between the plant and soil analyses. The trichomes are anti-herbivory or iridescent techniques of the plant. The sclereids around the vascular bundle are part of the desiccation prevention methods of the plant. The plant extracts had no effect on the microbial pathogens. Furthermore, there were no significant differences in metabolic parameters between the plant medicine and placebo group, except for the following: The mass of the Elytropappus rhinocerotic group was significantly higher (PS 0.05) at week two when compared to the placebo controls. On the other hand, the Elytropappus rhinocerotis group excreted less (P< 0.05) Cu at week 4 compared with the control group. The haematology indicated that the Elytropappus rhinocerotis group had elevated immune surveillance in that these animals had significantly higher (PS 0.05) levels of white blood cells, Neutrophils and Lymphocytes. The red blood cell parameters remained largely unaffected, except for mean cell haemoglobin concentration, which was higher (PS 0.05), and the mean cell volume, which was lower (P< 0.05) in the Elytropappus rhinocerotis group compared to the placebo. Moreover, there were no differences between the tissue architecture of both groups. This investigation has shown that Elytropappus rhinocerotic had no direct effect on microbial growth but significantly improved immune cell numbers, with minimal physiologically important effects on red blood cell parameters. These outcomes compel us to further study Elytropappus rhinocerotic as a potential anti-infective indigenous phytotherapy that may exert its effects via immune enhancement, especially when we consider its favorable safety profile. | en_US |
| dc.identifier.uri | https://hdl.handle.net/10566/17249 | |
| dc.language.iso | en | en_US |
| dc.publisher | University of the Western Cape | en_US |
| dc.rights.holder | University of the Western Cape | en_US |
| dc.subject | Elytropappus rhinocerotis Cass and Pelargonium triste | en_US |
| dc.subject | Herbal medicine | en_US |
| dc.subject | Indigenous medicinal systems | en_US |
| dc.subject | Oral traditions of the Khoi-San people | en_US |
| dc.subject | Traditional medicinal plants for ailments | en_US |
| dc.title | The effects of Elytropappus rhinocerotis Cass and Pelargonium triste (L.) L'Hèrit on animal health and metabolism | en_US |