Metronidazole in the Prophylaxis and treatment of Anaerobic Infection

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dc.contributor.authorApplebaum, P.C.
dc.contributor.authorMoodley, J.
dc.contributor.authorChatterton, S.A.
dc.contributor.authorCowan, D.B.
dc.contributor.authorAfrica, Charlene W.J.
dc.date.accessioned2014-01-09T07:39:25Z
dc.date.available2014-01-09T07:39:25Z
dc.date.issued1978
dc.description.abstractThe influence of prophylactic metronidazole on vaginal carriage rates of anaerobes and the development of postoperative anaerobic infection was studied in 104 women who underwent abdominal hysterectomy. Metronidazole prophylaxis in 54 patients led to a decrease in the anaerobe vaginal carriage rate from 65% pre-operatively to 17% and 28% on the 3rd and 7th postoperative days respectively. In the control group (50 patients) no significant decrease in anaerobe yield was noted, corresponding percentages being 72%, 64%, and 74%. Postoperative infection occurred in 36 patients (28 controls; 8 on prophylactic metronidazole). Wound swabs from all 8 patients in the latter group yielded aerobes, and in 1 patient mixed infection (aerobes/anaerobes) occurred. In 7 of these patients (including the patient with mixed infection), the infection resolved spontaneously, while the 8th patient responded to therapy with metronidazole, kanamycin and ampicillin. In the control patients, 21 cases of postoperative wound infection and 4 of vault infection were seen; wound swabs from patients in the former group yielded aerobes in only 6 cases, and mixed growth of aerobes/ anaerobes in 10 cases. Postoperative wound/vault infections in control patients cleared spontaneously in 18 cases and responded to imidazole therapy, with or without ampicillin and kanamycin, in 7 cases.en_US
dc.description.accreditationWeb of Scienceen_US
dc.identifier.citationApplebaum, P.C., et al. (1978). Metronidazole in the Prophylaxis and treatment of Anaerobic Infection. South African Medical Journal, 58: 703-706en_US
dc.identifier.issn0256-9574
dc.identifier.urihttp://hdl.handle.net/10566/923
dc.language.isoenen_US
dc.privacy.showsubmitterfalse
dc.publisherHealth and Medical Publishing Groupen_US
dc.rights© 1978 Appelbaum et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
dc.status.ispeerreviewedtrue
dc.subjectMetronidazoleen_US
dc.subjectAnaerobic infectionen_US
dc.titleMetronidazole in the Prophylaxis and treatment of Anaerobic Infectionen_US
dc.typeArticleen_US

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