Detection of selective Tyrosinase inhibitors from some South African plant extracts of Lamiaceae family
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Date
2016
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Publisher
University of the Western Cape
Abstract
Various dermatological disorders, such as formation of black pigmented patches on the surface
of the skin arise from the over-activity of tyrosinase enzyme's degenerative action. This enzyme
is further implicated in the involvement of melanin in malignant melanoma, the most lifethreatening
skin tumors. Although, synthetic products were found effective to combat this
menace, nevertheless, overtime detrimental effect on human skin is a challenge. Investigation of
natural tyrosinase inhibitors from methanol extracts of medicinal plants of Lamiaceae family
using L-tyrosine as substrate on three different complementary assays (TLC bio-autography,
spectrophotometry and cyclic voltammetry) was carried out accordingly.
Description
Magister Scientiae - MSc (Chemistry)