Evaluation of selected polycyclic compounds as resistance modulators in Mycobacterium tuberculosis

dc.contributor.advisorMalan, Sarel
dc.contributor.authorKapp, Erika
dc.date.accessioned2023-02-23T09:18:16Z
dc.date.accessioned2024-05-15T07:16:51Z
dc.date.available2023-02-23T09:18:16Z
dc.date.available2024-05-15T07:16:51Z
dc.date.issued2022
dc.descriptionDoctor Pharmaceuticae - DPharmen_US
dc.description.abstractProgressive development of resistance to various chemotherapeutic agents used in the management of infectious diseases presents a serious problem in global public health. Increasing levels of antimicrobial resistance in Mycobacterium tuberculosis (Mtb) is particularly concerning in resource poor countries with a high incidence of tuberculosis (TB), as it is particularly difficult and very costly to treat. The Global Tuberculosis report released by the World health Organization (WHO) in 2022 (based on data from 2021) reports that South Africa is one of only 5 countries in the world with more than 500 cases per 100 000 people. It also falls in the WHO’s top 7 countries with the highest multidrug resistant (MDR) TB incidence.1 The same report released in 2021 states that global TB reporting rates dropped dramatically in 2020, and that TB death rates saw the first year-on-year increase since 2005.2 This is likely a direct consequence of COVID-19 and although improvements in reporting was seen in 2021, the trend has not yet been reversed.1 The pandemic had a negative impact on the progress made in the fight against TB and a renewed effort is needed to achieve the goals previously set out in the WHO End TB Strategy.en_US
dc.identifier.urihttps://hdl.handle.net/10566/15060
dc.language.isoenen_US
dc.publisherUniversity of the Western Capeen_US
dc.rights.holderUniversity of the Western Capeen_US
dc.subjectMycobacterium tuberculosisen_US
dc.subjectPublic healthen_US
dc.subjectTuberculosisen_US
dc.subjectWorld Health Organization (WHO)en_US
dc.subjectSouth Africaen_US
dc.subjectCovid-19en_US
dc.titleEvaluation of selected polycyclic compounds as resistance modulators in Mycobacterium tuberculosisen_US

Files

Original bundle
Now showing 1 - 1 of 1
Loading...
Thumbnail Image
Name:
kapp_phd_nsc_2022.pdf
Size:
8.47 MB
Format:
Adobe Portable Document Format
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.71 KB
Format:
Plain Text
Description: