Investigation of the anti-cancer and apoptotic properties of aqueous extract from fermented African locust bean seeds

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dc.contributor.authorSibuyi, N.R
dc.contributor.authorAyo-Lawal, R.A
dc.contributor.authorEkpo, O
dc.date.accessioned2021-05-24T10:15:38Z
dc.date.available2021-05-24T10:15:38Z
dc.date.issued2021
dc.description.abstractSome fermented foods are reported to possess anti-cancer properties. Fermented African locust bean seeds is a condiment prepared from fermentation of Parkia biglobosa. It has been reportedly functional for various medicinal activities but not anti-cancer. The cytotoxic and apoptosis-inducing properties of the aqueous extract of the condiment were investigated in human cancer-hepatocellular (Hep-G2) and cervical (HeLa) and non-cancer cell lines. Cytotoxicity was evaluated using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) and clonogenic cell survival assays. Apoptotic cell death and DNA fragmentation were also investigated. The results revealed cytotoxicity to both cell lines in a dose-dependent manner (P < 0.05) and selective activities between cancer and non-cancer cells. The IC50 values were 1.3 and 0.5 mg/mL for Hep-G2 and HeLa cells respectively. Furthermore, the extract induced apoptotic cell death in only Hep-G2 (73.03±0.73) cells.en_US
dc.identifier.citationSibuyi, N.R. et al. (2021). Investigation of the anti-cancer and apoptotic properties of aqueous extract from fermented African locust bean seeds. Food Research, 5(1), 203-210en_US
dc.identifier.issn2550-2166
dc.identifier.uri10.26656/fr.2017.5(1).295
dc.identifier.urihttp://hdl.handle.net/10566/6191
dc.language.isoenen_US
dc.publisherRynnye Lyan Resourcesen_US
dc.subjectAnti-canceren_US
dc.subjectApoptoticen_US
dc.subjectCytotoxicityen_US
dc.subjectDNA fragmentationen_US
dc.subjectFermented African locust bean seedsen_US
dc.subjectFermented Parkia biglobosaen_US
dc.titleInvestigation of the anti-cancer and apoptotic properties of aqueous extract from fermented African locust bean seedsen_US
dc.typeArticleen_US

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