Causes and consequences of sperm mitochondrial dysfunction

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dc.contributor.authorDurairajanayagam, D.
dc.contributor.authorSingh, D.
dc.contributor.authorAgarwal, A.
dc.contributor.authorHenkel, R.
dc.date.accessioned2020-11-17T13:00:27Z
dc.date.available2020-11-17T13:00:27Z
dc.date.issued2020
dc.description.abstractMitochondria have multiple functions, including synthesis of adenine triphosphate, production of reactive oxygen species, calcium signalling, thermogenesis and apoptosis. Mitochondria have a significant contribution in regulating the various physiological aspects of reproductive function, from spermatogenesis up to fertilisation. Mitochondrial functionality and intact mitochondrial membrane potential are a prerequisite for sperm motility, hyperactivation, capacitation, acrosin activity, acrosome reaction and DNA integrity. Optimal mitochondrial activity is therefore crucial for human sperm function and semen quality. However, the precise role of mitochondria in spermatozoa remains to be fully explored. Defects in sperm mitochondrial function severely impair the maintenance of energy production required for sperm motility and may be an underlying cause of asthenozoospermia. Sperm mtDNA is susceptible to oxidative damage and mutations that could compromise sperm function leading to infertility. Males with abnormal semen parameters have increased mtDNA copy number and reduced mtDNA integrity. This review discusses the role of mitochondria in sperm function, along with the causes and impact of its dysfunction on male fertility. Greater understanding of sperm mitochondrial function and its correlation with sperm quality could provide further insights into their contribution in the assessment of the infertile male.en_US
dc.identifier.citationDurairajanayagam D. et al. (2020). Causes and consequences of sperm mitochondrial dysfunction. Andrologia,e13666.en_US
dc.identifier.issn03034569
dc.identifier.urihttp://hdl.handle.net/10566/5444
dc.identifier.urihttps://doi.org/10.1111/and.13666
dc.language.isoenen_US
dc.publisherWiley-Blackwellen_US
dc.subjectMale infertilityen_US
dc.subjectMitochondrial DNAen_US
dc.subjectMitochondrial membrane potentialen_US
dc.subjectOxidative stressen_US
dc.subjectSperm mitochondriaen_US
dc.titleCauses and consequences of sperm mitochondrial dysfunctionen_US
dc.typeArticleen_US

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