Transforming RNA-Seq gene expression to track cancer progression in the multi-stage early to advanced-stage cancer development

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dc.contributor.authorLivesey, Michelle
dc.contributor.authorRossouw, Sophia Catherine
dc.contributor.authorBlignaut, Renette
dc.date.accessioned2023-05-09T08:46:01Z
dc.date.available2023-05-09T08:46:01Z
dc.date.issued2023
dc.description.abstractCancer progression can be tracked by gene expression changes that occur throughout early-stage to advanced-stage cancer development. The accumulated genetic changes can be detected when gene expression levels in advanced-stage are less variable but show high variability in early-stage. Normalizing advanced-stage expression samples with earlystage and clustering of the normalized expression samples can reveal cancers with similar or different progression and provide insight into clinical and phenotypic patterns of patient samples within the same cancer.en_US
dc.identifier.citationLivesey, M. et al. (2023). Transforming RNA-Seq gene expression to track cancer progression in the multi-stage early to advanced-stage cancer development. PLoS ONE, 18(4 APRIL), e0284458. https://doi.org/10.1371/journal.pone.0284458en_US
dc.identifier.issn1932-6203
dc.identifier.urihttps://doi.org/10.1371/journal.pone.0284458
dc.identifier.urihttp://hdl.handle.net/10566/8909
dc.language.isoenen_US
dc.publisherPublic Library of Scienceen_US
dc.subjectFemaleen_US
dc.subjectTesticular neoplasmsen_US
dc.subjectCanceren_US
dc.subjectStatistics studiesen_US
dc.subjectuterine cervix tumoren_US
dc.titleTransforming RNA-Seq gene expression to track cancer progression in the multi-stage early to advanced-stage cancer developmenten_US
dc.typeArticleen_US

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