Imino-phospine palladium (II) and platinum (II) complexes: Synthesis, molecular structures and evaluation as antitumor agents

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dc.contributor.authorMotswainyana, William M.
dc.contributor.authorOnani, Martin O.
dc.contributor.authorMadiehe, Abram M.
dc.contributor.authorSaibu, Morounke
dc.contributor.authorThovhogi, Ntevheleni
dc.contributor.authorLalancette, Roger A.
dc.date.accessioned2018-02-28T15:06:09Z
dc.date.available2018-02-28T15:06:09Z
dc.date.issued2013
dc.description.abstractThe imino-phosphine ligands L1 and L2 were prepared via condensation reaction of 2-(diphenylphosphino) benzaldehyde with substituted anilines and obtained in very good yields. An equimolar reaction of L1 and L2 with either PdCl2(cod) or PtCl2(cod) gave new palladium(II) and platinum(II) complexes 1–4. The compounds were characterized by elemental analysis, IR, 1H and 31P NMR spectroscopy. The molecular structures of 2, 3 and 4 were confirmed by X-ray crystallography. All the three molecular structures crystallized in monoclinic C2/c space system. The coordination geometry around the palladiumand platinumatoms in respective structures exhibited distorted square planar geometry at the metal centers. The complexes were evaluated in vitro for their cytotoxic activity against human breast (MCF-7) and human colon (HT-29) cancer cells, and they exhibited growth inhibitory activities and selectivity that were superior to the standard compound cisplatin.en_US
dc.description.accreditationWeb of Science
dc.identifier.citationMotswainyana, W.M. et al. (2013). Imino-phosphine palladium(II) and platinum(II) complexes : Synthesis, molecular structures and evaluation as antitumor agents. Journal of Inorganic Biochemistry, 129: 112 – 118.en_US
dc.identifier.issn0162-0134
dc.identifier.urihttp://dx.doi.org/10.1016/j.jinorgbio.2013.09.010
dc.identifier.urihttp://hdl.handle.net/10566/3550
dc.language.isoenen_US
dc.privacy.showsubmitterFALSE
dc.publisherElsevieren_US
dc.rightsThis is the author-version of the article published online at: http://dx.doi.org/10.1016/j.jinorgbio.2013.09.010
dc.status.ispeerreviewedTRUE
dc.subjectImino-phosphineen_US
dc.subjectPalladiumen_US
dc.subjectPlatinumen_US
dc.subjectSynthesisen_US
dc.subjectMolecular structuresen_US
dc.subjectAntitumoren_US
dc.titleImino-phospine palladium (II) and platinum (II) complexes: Synthesis, molecular structures and evaluation as antitumor agentsen_US
dc.typeArticleen_US

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