Pharmaceutical co-crystal: An alternative strategy for enhanced physicochemical properties and drug synergy

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Date

2020

Journal Title

Journal ISSN

Volume Title

Publisher

Wiley Open Access

Abstract

A growing number of co-crystals in the literature are proof of how significant the co-crystallization concept has become. Co-crystallization enhances physicochemical properties through the formation of intermolecular interactions between a drug and a co-former. A co-crystal is a single crystalline material consisting of at least two molecular components solid at room temperature and present in a definite stoichiometric ratio. Pharmaceutical co-crystals consist of the active pharmaceutical ingredient and the co-former selected from generally regarded as safe (GRAS) list of the United State Food and Drug Administration.

Description

Keywords

Co-crystal development, Co-crystallization, Design, Pharmaceutical co-crystals, Synergistic co-crystals

Citation

Ngilirabanga, Jean & Samsodien, Halima. (2021). Pharmaceutical co‐crystal: An alternative strategy for enhanced physicochemical properties and drug synergy. Nano Select. 2. 10.1002/nano.202000201.