Pharmaceutical co-crystal: An alternative strategy for enhanced physicochemical properties and drug synergy
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Date
2020
Authors
Journal Title
Journal ISSN
Volume Title
Publisher
Wiley Open Access
Abstract
A growing number of co-crystals in the literature are proof of how significant
the co-crystallization concept has become. Co-crystallization enhances
physicochemical properties through the formation of intermolecular interactions
between a drug and a co-former. A co-crystal is a single crystalline material
consisting of at least two molecular components solid at room temperature and
present in a definite stoichiometric ratio. Pharmaceutical co-crystals consist of
the active pharmaceutical ingredient and the co-former selected from generally
regarded as safe (GRAS) list of the United State Food and Drug Administration.
Description
Keywords
Co-crystal development, Co-crystallization, Design, Pharmaceutical co-crystals, Synergistic co-crystals
Citation
Ngilirabanga, Jean & Samsodien, Halima. (2021). Pharmaceutical co‐crystal: An alternative strategy for enhanced physicochemical properties and drug synergy. Nano Select. 2. 10.1002/nano.202000201.