Cochrane corner: beta-blockers for hypertension

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dc.contributor.authorWiysonge, Charles S.
dc.contributor.authorBradley, Hazel A.
dc.contributor.authorVolmink, Jimmy
dc.contributor.authorMayosi, Bongani M.
dc.date.accessioned2018-09-03T11:59:56Z
dc.date.available2018-09-03T11:59:56Z
dc.date.issued2017
dc.description.abstractBeta-blockers refer to an assorted group of medications that block the action of endogenous catecholamines on beta-adrenergic receptors.1 The ß1 and ß2 receptorsare the primary beta-adrenergic receptors in the human cardiovascular system. Beta- blockers differ in their ß1/ ß2-receptor selectivity and vasodilatory properties. Based on this diversity, beta-blockers have been categorised into first, second and third generation. First-generation beta-blockers, also referred to as non-selective blockers, possess equal affinity for ß1 and ß2 receptors. Second-generation (or selective) beta-blockers exercise more affinity for ß1 than ß2 receptors. Neither of these traditional beta-blockers has vasodilatory properties, which is an intrinsic characteristic of third-generation beta-blockers.en_US
dc.description.accreditationISI
dc.identifier.citationWiysonge, C.S. et al. 2017. Cochrane corner: beta-blockers for hypertension. Heart, 2017 0:1.en_US
dc.identifier.urihttp://dx.doi.org/10.1136/heartjnl-2017-311585
dc.identifier.urihttp://hdl.handle.net/10566/3995
dc.language.isoenen_US
dc.privacy.showsubmitterFALSE
dc.publisherBMJ Publishing Groupen_US
dc.rightsThis is the author-version of the article published online at: http://dx.doi.org/10.1136/heartjnl-2017-311585
dc.status.ispeerreviewedTRUE
dc.subjectBeta-blockersen_US
dc.subjectHypertensionen_US
dc.subjectEndogenous catecholaminesen_US
dc.subjectBeta-adrenergic receptorsen_US
dc.titleCochrane corner: beta-blockers for hypertensionen_US
dc.typeArticleen_US

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