Sutherlandiosides e−k: further cycloartane glycosides from sutherlandia frutescens
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Date
2024
Journal Title
Journal ISSN
Volume Title
Publisher
Elsevier Ltd
Abstract
A further chemical investigation of the butanol extract of leaves from the South African medicinal plant Sutherlandia frutescens led to the isolation of eight previously unreported saponins (1−8), together with the known sutherlandio sides A−D. Their structures were established by spectroscopic (1D and 2D NMR) analyses, CD, optical rotation, mass spectrometry, as well as chemical conversions. The isolates were screened for their cytotoxic activity against the MCF-7 human breast cancer cell line, although no significant activity was observed. In addition to the chemophenetic markers for this genus, i.e. the cycloartane glycosides, the present work also reports on the first isolation of an oleanan-type saponin from the Sutherlandia genus, forming an important fingerprint for the chemical composition of the plant.
Description
Keywords
Cycloartanes, Saponins, Sutherlandia frutescens, Sutherlandiosides, Glycoside
Citation
Tchegnitegni, B.T., Lerata, M.S., Beukes, D.R. and Antunes, E.M., 2024. Sutherlandiosides E− K: Further cycloartane glycosides from Sutherlandia frutescens. Phytochemistry Letters, 61, pp.66-74.