Multifunctional Gold Nanoparticles for Improved Diagnostic and Therapeutic Applications: A Review

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dc.contributor.authorSibuyi, NR
dc.contributor.authorMoabelo, K
dc.contributor.authorMeyer, M
dc.date.accessioned2022-03-07T19:05:51Z
dc.date.available2022-03-07T19:05:51Z
dc.date.issued2021
dc.description.abstractThe medical properties of metals have been explored for centuries in traditional medicine for the treatment of infections and diseases and still practiced to date. Platinum-based drugs are the first class of metal-based drugs to be clinically used as anticancer agents following the approval of cisplatin by the United States Food and Drug Administration (FDA) over 40 years ago. Since then, more metals with health benefits have been approved for clinical trials. Interestingly, when these metals are reduced to metallic nanoparticles, they displayed unique and novel properties that were superior to their bulk counterparts. Gold nanoparticles (AuNPs) are among the FDA-approved metallic nanoparticles and have shown great promise in a variety of roles in medicine. They were used as drug delivery, photothermal (PT), contrast, therapeutic, radiosensitizing, and gene transfection agents. Their biomedical applications are reviewed herein, covering their potential use in disease diagnosis and therapy. Some of the AuNP-based systems that are approved for clinical trials are also discussed, as well as the potential health threats of AuNPs and some strategies that can be used to improve their biocompatibility. The reviewed studies offer proof of principle that AuNP-based systems could potentially be used alone or in combination with the conventional systems to improve their efficacy.en_US
dc.identifier.citationSibuyi, Nicole & Moabelo, Koena & Adewale, Oluwaseun, Fadaka & Meyer, Samantha & Onani, Martin & Madiehe, Abram & Meyer, Mervin. (2021). Multifunctional Gold Nanoparticles for Improved Diagnostic and Therapeutic Applications: A Review. Nanoscale Research Letters. 16. 10.1186/s11671-021-03632-w.en_US
dc.identifier.issn1556-276X
dc.identifier.uri10.1186/s11671-021-03632-w
dc.identifier.urihttp://hdl.handle.net/10566/7303
dc.language.isoenen_US
dc.publisherSpringer Openen_US
dc.subjectDrug deliveryen_US
dc.subjectBio-functionalizationen_US
dc.subjectGold nanoparticlesen_US
dc.subjectMetal-based therapyen_US
dc.subjectMultimodal systemsen_US
dc.titleMultifunctional Gold Nanoparticles for Improved Diagnostic and Therapeutic Applications: A Reviewen_US
dc.typeArticleen_US

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