Acyldepsipeptide analogues: A future generation antibiotics for Tuberculosis treatment

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dc.contributor.authorCobongela, Sinazo Z. Z.
dc.contributor.authorMakatini, Maya M.
dc.contributor.authorSibuyi, Nicole R. S.
dc.date.accessioned2022-10-11T08:19:29Z
dc.date.available2022-10-11T08:19:29Z
dc.date.issued2022
dc.description.abstractAcyldepsipeptides (ADEPs) are a new class of emerging antimicrobial peptides (AMPs), which are currently explored for treatment of pathogenic infections, including tuberculosis (TB). These cyclic hydrophobic peptides have a unique bacterial target to the conventional anti-TB drugs, and present a therapeutic window to overcome Mycobacterium Tuberculosis (M. tb) drug resistance. ADEPs exerts their antibacterial activity on M. tb strains through activation of the protein homeostatic regulatory protease, the caseinolytic protease (ClpP1P2). ClpP1P2 is normally regulated and activated by the ClpP-ATPases to degrade misfolded and toxic peptides and/or short proteins. ADEPs bind and dysregulate all the homeostatic capabilities of ClpP1P2 while inducing non-selective proteolysis. The uncontrolled proteolysis leads to M. tb cell death within the host.en_US
dc.identifier.citationCobongela, S. Z. Z. et al. (2022). Acyldepsipeptide analogues: A future generation antibiotics for Tuberculosis treatment. Pharmaceutics, 14(9),1956. https://doi.org/10.3390/pharmaceutics14091956en_US
dc.identifier.issn1999-4923
dc.identifier.urihttps://doi.org/10.3390/pharmaceutics14091956
dc.identifier.urihttp://hdl.handle.net/10566/8036
dc.language.isoenen_US
dc.publisherMDPIen_US
dc.subjectAcyldepsipeptidesen_US
dc.subjectAntimicrobial peptidesen_US
dc.subjectTuberculosisen_US
dc.subjectMycobacterium tuberculosisen_US
dc.subjectPharmaceuticsen_US
dc.titleAcyldepsipeptide analogues: A future generation antibiotics for Tuberculosis treatmenten_US
dc.typeArticleen_US

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