Candida species carriage in diabetic patients in Misrata, Libya

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dc.contributor.authorEsmaio, Mustafa Hassan Mustafa
dc.contributor.authorAbrantes, Pedro Miguel dos Santos
dc.contributor.authorAfrica, Charlene Wilma Joyce
dc.date.accessioned2019-03-06T06:15:32Z
dc.date.available2019-03-06T06:15:32Z
dc.date.issued2017
dc.description.abstractBackground: There is a paucity of studies describing the prevalence and antimicrobial profiles of Candida in Libya. Limited treatment choices in the antifungal armamentarium in public healthcare settings in Africa require a study of the prevalence and susceptibility of Candida species in Libya, where antifungals are not routinely prescribed in public healthcare settings. Methods: In this study, 170 diabetes mellitus type 2 (T2DM) patients were examined for Candida carriage in the oral mucosa, using differential Fluka and Oxoid chromogenic media and API 32 ID C biochemical testing. Fluconazole susceptibility was investigated by disk diffusion on YNBG agar. Isolates were graded as susceptible, intermediate or resistant according to their inhibition zone measurements and microcolony scores. Results: Thirteen species were identified from 182 isolates with a frequency of 68 C. albicans, 42 C. dubliniensis, 26 C. humicola, 20 C. glabrata , 5 isolates of each C. krusei, C. tropicalis and C. kefyr, 4 C. sake, 2 C. parapsilopsis, 2 C. magnoliae and 1 isolate each of C. guilliermondii, C. globosa and C. membranifaciens. Although largely susceptible to fluconazole, C. albicans, C. dubliniensis, C. humicola and C. sake demonstrated an emerging resistance with intermediate to total resistance observed in all the other species except for C. magnolia and C. globosa which were both susceptible to fluconazole. Conclusion: Early recognition and treatment of rare or resistant Candida species which may be contributing to patient morbidity and mortality in Libya is imperative.en_US
dc.identifier.citationEsmaio MHM, Abrantes PMDS, Africa CWJ. (2017). Candida species carriage in diabetic patients in Misrata, Libya. South African Journal of Infectious Diseases. 32(4):ID8321en_US
dc.identifier.issn2312-0053
dc.identifier.urihttp://hdl.handle.net/10566/4348
dc.language.isoenen_US
dc.publisherMedpharm Publicationsen_US
dc.relation.ispartofseriesFederation of Infectious Diseases Societies of Southern Africa 7th Congress;ID8321
dc.subjectMycologyen_US
dc.subjectCandidaen_US
dc.subjectLibyaen_US
dc.subjectDiabetes mellitus type 2en_US
dc.titleCandida species carriage in diabetic patients in Misrata, Libyaen_US
dc.typePresentationen_US

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