A diverse array of genetic factors contribute to the pathogenesis of Systemic Lupus Erythematosus

Simple item page
dc.contributor.authorTiffin, Nicki
dc.contributor.authorAdeyemo, Adebowale A.
dc.contributor.authorOkpechi, Ikechi
dc.date.accessioned2017-02-17T09:53:39Z
dc.date.available2017-02-17T09:53:39Z
dc.date.issued2013
dc.description.abstractSystemic lupus erythematosus (SLE) is a chronic systemic autoimmune disease with variable clinical presentation frequently affecting the skin, joints, haemopoietic system, kidneys, lungs and central nervous system. It can be life threatening when major organs are involved. The full pathological and genetic mechanisms of this complex disease are yet to be elucidated; although roles have been described for environmental triggers such as sunlight, drugs and chemicals, and infectious agents. Cellular processes such as inefficient clearing of apoptotic DNA fragments and generation of autoantibodies have been implicated in disease progression. A diverse array of disease-associated genes and microRNA regulatory molecules that are dysregulated through polymorphism and copy number variation have also been identified; and an effect of ethnicity on susceptibility has been described.en_US
dc.description.accreditationISI
dc.description.urihttp://dx.doi.org/10.1186/1750-1172-8-2
dc.identifier.citationTiffin, N. et al. (2013). A diverse array of genetic factors contribute to the pathogenesis of Systemic Lupus Erythematosus. Orphanet Journal of Rare Diseases, 8(2)en_US
dc.identifier.issn1750-1172
dc.identifier.urihttp://hdl.handle.net/10566/2543
dc.identifier.urihttp://dx.doi.org/10.1186/1750-1172-8-2
dc.language.isoenen_US
dc.privacy.showsubmitterFALSE
dc.publisherBiomed Centralen_US
dc.rightsThis is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
dc.status.ispeerreviewedTRUE
dc.subjectSystemic lupus erythematosusen_US
dc.subjectAutoimmunityen_US
dc.subjectGenetic susceptibilityen_US
dc.subjectApoptosisen_US
dc.subjectdsDNAen_US
dc.subjectDisease genesen_US
dc.titleA diverse array of genetic factors contribute to the pathogenesis of Systemic Lupus Erythematosusen_US
dc.typeArticleen_US

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Tiffin_ A diverse array_2013.pdf
Size:
795.02 KB
Format:
Adobe Portable Document Format
Description:
Download

Collections

Research Articles (SANBI)
Research Articles (Medical Bioscience)