Preparation and evaluation of pralidoxime-loaded plga nanoparticles as potential carriers of the drug across the blood brain barrier

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dc.contributor.authorChigumira, Washington
dc.contributor.authorMaposa, Prosper
dc.contributor.authorDube, Admire
dc.date.accessioned2023-07-03T10:20:37Z
dc.date.available2023-07-03T10:20:37Z
dc.date.issued2015
dc.description.abstractPralidoxime is an organophosphate antidote with poor central nervous system distribution due to a high polarity. In the present study, pralidoxime-loaded poly(lactic-co-glycolic acid) nanoparticles were prepared and evaluated as a potential delivery system of the drug into the central nervous system. The nanoparticles were prepared using double emulsion solvent evaporation method. Poly(lactic-co-glycolic acid) (PLGA) in ethyl acetate made the organic phase and pralidoxime in water made the aqueous phase.The system was stabilized by polyvinyl alcohol. Different drug/polymer ratios were used (1 : 1, 1 : 2, and 1 : 4) and the fabricated particles were characterized for encapsulation efficiency using UV-VIS Spectroscopy; particle size distribution, polydispersity index, and zeta potential using photon correlation spectroscopy; and in vitro drug release profile using UV-VIS Spectroscopy. Mean particle sizes were 386.6 nm, 304.7 nm, and 322.8 nm, encapsulation efficiency was 28.58%, 51.91%, and 68.78%, and zeta potential was 5.04 mV, 3.31 mV, and 5.98 mV for particles with drug/polymer ratios 1 : 1, 1 : 2, and 1 : 4, respectively. In vitro drug release profile changed from biphasic to monobasic as the drug/polymer ratio decreased from 1 : 1 to 1 : 4. Stable pralidoxime-loaded PLGA nanoparticles were produced using double emulsion solvent evaporation techniques.en_US
dc.identifier.citationChigumira, W. et al. (2015). Preparation and evaluation of pralidoxime-loaded plga nanoparticles as potential carriers of the drug across the blood brain barrier. Journal of Nanomaterials, 692672. https://doi.org/10.1155/2015/692672en_US
dc.identifier.issn1687-4129
dc.identifier.urihttps://doi.org/10.1155/2015/692672
dc.identifier.urihttp://hdl.handle.net/10566/9182
dc.language.isoenen_US
dc.publisherHindawien_US
dc.subjectChemistryen_US
dc.subjectNanoparticlesen_US
dc.subjectPharmaceuticalsen_US
dc.subjectSouth Africaen_US
dc.titlePreparation and evaluation of pralidoxime-loaded plga nanoparticles as potential carriers of the drug across the blood brain barrieren_US
dc.typeArticleen_US

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