In-vitro cytotoxicity, anti-bacterial and anti-inflammatory activities of ecklonia radiataand jania verrucosafrom Eastern Cape, South Africa

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dc.contributor.authorSaibu, Gbemisola M.
dc.contributor.authorVincent, Nakin M.
dc.contributor.authorOlawale, Fadaka O.
dc.date.accessioned2023-04-14T11:46:13Z
dc.date.available2023-04-14T11:46:13Z
dc.date.issued2022
dc.description.abstractSeaweeds are marine floras constituting in part to over 90% of the oceanic biomass. Despite the enrichments of seaweeds, their potentials are largely unexplored. Hence, this study evaluated the phytochemical screening, antimicrobial, anti-inflammatory and cytotoxicity activities of methanolic extracts of Ecklonia radiata and Jania verrucosa. E. radiata and J. verrucosa were collected from sites on the rocky shores of the Mbashe and Port St. John rivers on the Eastern Cape coast of South Africa during spring low tides. Qualitative phytochemical screening was carried out using standard protocol. The assessment of anti-inflammatory activity was done by inhibition of albumin denaturation assay and antimicrobial analysis was performed against six different pathogenic clinical isolates. The cytotoxicity effect of the methanolic extracts were further investigated on MDA-MB-231, HepG2, CaCo-2 and KMST-6 by (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) tetrazolium reduction assay (MTT assay). Phytochemical analysis revealed the presence of tannins, phenols, glycosides, and alkaloid for both extracts. The methanolic extracts of both seed weeds also possess anti-inflammatory activity by inhibiting albumin denaturation.en_US
dc.identifier.citationSaibu, G. M. et al. (2022). In-vitro cytotoxicity, anti-bacterial and anti-inflammatory activities of ecklonia radiataand jania verrucosafrom Eastern Cape, South Africa. Tropical Journal of Natural Product Research, 7(1), 2122-2127. http://www.doi.org/10.26538/tjnpr/v7i1.6en_US
dc.identifier.issn2616-0692
dc.identifier.urihttp://www.doi.org/10.26538/tjnpr/v7i1.6
dc.identifier.urihttp://hdl.handle.net/10566/8805
dc.language.isoenen_US
dc.publisherUniversity of Beninen_US
dc.subjectSeaweedsen_US
dc.subjectAnti-microbialen_US
dc.subjectAnti-inflammatoryen_US
dc.subjectPhytochemicalen_US
dc.subjectSouth Africaen_US
dc.titleIn-vitro cytotoxicity, anti-bacterial and anti-inflammatory activities of ecklonia radiataand jania verrucosafrom Eastern Cape, South Africaen_US
dc.typeArticleen_US

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