Genetic association of solute carrier transporter gene variants with metformin response

Simple item page
dc.contributor.authorPearce, Brendon
dc.contributor.authorbrahams-October, Z
dc.contributor.authorXhakaza, L
dc.date.accessioned2021-09-22T18:51:05Z
dc.date.available2021-09-22T18:51:05Z
dc.date.issued2021
dc.description.abstractType 2 diabetes mellitus (T2DM) is a metabolic disorder characterized by elevated blood glucose levels and is influenced by both genetic and environmental factors. It is treated with various classes of oral antidiabetic drugs, however, response to treatment is highly variable with patients failing to achieve adequate glycemic control. Treatment response variability has been associated with single nucleotide polymorphisms (SNPs) which influence the pharma-cokinetics and pharmacodynamics of drug(s). The aim of this study was to evaluate the genetic association of 17 SNPs and the response to metformin therapy in patients diagnosed with diabetes from the indigenous Nguni population of South Africa. One hundred and forty indigenous African patients diagnosed with T2DM were recruited and genotyped using the MassARRAY® system. Therapeutic response of patients was ascertained by a change in Hb A1c. Two SNPs (rs1801282 and rs6265) were monomorphic. All other variants were within the Hardy- Weinberg equilibrium (HWE). The T allele of the SLC variant rs316009 [odds ratio (OR) = 0.25, 95% confidence interval (95% CI) = 0.01-0.09, p value = 0.044] and the CT genotype of the PCK1 variant rs4810083 (OR = 2.80, 95% CI = 1.01-7.79, p value = 0.049) were associated with an improved response to treatment after adjustment. No association was observed with post Bonferroni correction. Moreover, this study provides important additional data regarding possible associations between genetic variants and metformin therapy outcomes. In addition, this is one of the first studies providing genetic data from the understudied indigenous sub-Saharan African populations.en_US
dc.identifier.citationAbrahams-October, Z., Xhakaza, L., Pearce, B., Mandisa Masilela, C., Benjeddou, M., Vincent Adeniyi, O., Johnson, R., & Jebio Ongole, J. (2021). Genetic association of solute carrier transporter gene variants with metformin response. Balkan Journal of Medical Genetics, 24(1), 47–56. https://doi.org/10.2478/bjmg-2021-0004en_US
dc.identifier.uridoi.org/10.2478/bjmg-2021-0004
dc.identifier.urihttp://hdl.handle.net/10566/6784
dc.language.isoenen_US
dc.publisherBalkan Journal of Medical Geneticsen_US
dc.subjectsingle nucleotide polymorphisms (SNPs)en_US
dc.subjectSLC variantsen_US
dc.subjectSouth African cohorten_US
dc.subjecttreatment responseen_US
dc.subjecttype 2 diabetes mellitus (T2DM)en_US
dc.titleGenetic association of solute carrier transporter gene variants with metformin responseen_US
dc.typeArticleen_US

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Genetic-association-of-solute-carrier-transporter-gene-variants-with-metformin-responseBalkan-Journal-of-Medical-Genetics.pdf
Size:
263.86 KB
Format:
Adobe Portable Document Format
Description:
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

Research Articles (Biotechnology)