Characterization of new pyrone-containing flavones from Helichrysum petiolare Hilliard & B.L. Burtt

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dc.contributor.authorMakhaba, Masixole
dc.contributor.authorYalo, Masande
dc.contributor.authorKoki, Mkhuseli
dc.contributor.authorNako, Ndikho
dc.contributor.authorMabusela, Wilfred T.
dc.contributor.authorPearce, Keenau
dc.contributor.authorBenjeddou, Mongi
dc.date.accessioned2025-10-27T08:56:53Z
dc.date.available2025-10-27T08:56:53Z
dc.date.issued2025
dc.description.abstractHelichrysum petiolare Hilliard & B.L. Burtt. (Asteraceae), native to the Cape Floral Region of South Africa, is traditionally used in the management of wounds, respiratory complaints, and diabetes. Although extensive studies on its extracts, few have focused on the bioactivity of the individual phytochemicals. In this study, chromatographic processing of the H. petiolare leaf total extract led to the isolation and identification of ten compounds C1–C10) using NMR, FTIR, and HRESIMS spectroscopy. Two pyrone-containing flavones (C1 and C2) are reported for the first time from natural sources. The known compounds identified included flavonoids (C3–C5), phenolics (C6–C9), and a sterol (C10). The MTT assay revealed dose-dependent cytotoxicity of C1–C4 only against MDA-MB-231 (breast cancer), HeLa (cervical cancer), and HEK-293 (non-cancerous kidney) cell lines after 24 h exposure. Notably, C4 demonstrated selective activity toward HeLa cells (45 % viability reduction at 100 µM; IC₅₀ = 89.19 µg/mL). This is the first report of compounds C1–C10 from H. petiolare and their in vitro cytotoxic profile. Despite moderate activity, this work provides a foundation for further pharmacological investigations of derivatives of these metabolites in cancer management.
dc.identifier.citationMakhaba, M., Yalo, M., Pearce, K., Koki, M., Nako, N., Sharma, R., Mabusela, W.T., Benjeddou, M. and Hussein, A.A., 2025. Characterization of new pyrone-containing flavones from Helichrysum petiolare Hilliard & BL Burtt. South African Journal of Botany, 186, pp.263-268.
dc.identifier.urihttps://doi.org/10.1016/j.sajb.2025.09.025
dc.identifier.urihttps://hdl.handle.net/10566/21137
dc.language.isoen
dc.publisherElsevier B.V.
dc.subjectAsteraceae
dc.subjectCytotoxicity
dc.subjectHelichrysum petiolare
dc.subjectPyrone-containing flavones
dc.subjectCape Floral Region of South Africa
dc.titleCharacterization of new pyrone-containing flavones from Helichrysum petiolare Hilliard & B.L. Burtt
dc.typeArticle

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