Derivatives of pyrazole-based compounds as prospective cancer agents

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dc.contributor.authorAlexander, Orbett T
dc.contributor.authorRamoba, Lesetja V.
dc.contributor.authorNzondomyo, Wakopo J.
dc.date.accessioned2025-08-01T13:33:51Z
dc.date.available2025-08-01T13:33:51Z
dc.date.issued2025
dc.description.abstractFive pyrazole-based compounds, 3,5-dimethyl-1H-pyrazole, L1; 3,5-diphenyl-1H-pyrazole, L2; 3-(trifluoromethyl)-5-phenyl-1H-pyrazole, L3; 3-(trifluoromethyl)-5-methyl-1H-pyrazole, L4; and 3,5-ditert-butyl-1H-pyrazole, L5 were synthesized from a typical condensation reaction of β-diketone derivatives with hydrazine hydrate reagent and characterized using various spectroscopic techniques such as FT-IR, UV-vis, 1H and 13C NMR, and LC-MS spectroscopy. L1 was further analyzed by single-crystal X-ray diffraction, and the N1-N1′ bond distance was found to be 1.361(3) Å and correlated well with other pyrazole-based compounds. The short-term cytotoxicity of 10 μM pyrazole compounds (L1-L5) was evaluated against pancreatic (CFPAC-1 and PANC-1), breast (MDA-MB-231 and MCF-7), and cervical (CaSki and HeLa) cancer cell lines using the MTT cell viability assay. Cisplatin and gemcitabine were included as positive control drugs followed by the determination of the half-maximal effective concentrations of prospective compounds. L2 and L3, respectively, displayed moderate cytotoxicity against CFPAC-1 (61.7 ± 4.9 μM) and MCF-7 (81.48 ± 0.89 μM) cell lines.
dc.identifier.citationRamoba, L.V., Nzondomyo, W.J., Serala, K., Macharia, L.W., Biswas, S., Prince, S., Malan, F.P., Alexander, O.T. and Manicum, A.L.E., 2025. Derivatives of pyrazole-based compounds as prospective cancer agents. ACS omega, 10(12), pp.12671-12678.
dc.identifier.urihttps://doi.org/10.1021/acsomega.5c00320
dc.identifier.urihttps://hdl.handle.net/10566/20649
dc.language.isoen
dc.publisherAmerican Chemical Society
dc.subjectReaxys retrieves substances
dc.subjectsubstance properties
dc.subjectreaction and synthesis data.
dc.subjectPyrazole-Based Compound
dc.subjectPyrazoles
dc.titleDerivatives of pyrazole-based compounds as prospective cancer agents
dc.typeArticle

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