Mugabo, PierreEzeukwu, Ifeoma Patricia2018-08-022024-05-152018-08-022024-05-152017https://hdl.handle.net/10566/15163Magister Pharmaceuticae - MpharmMany studies have investigated the pharmacokinetics (PK) of anti-tuberculosis drugs in tuberculosis patients. However, currently in South Africa, no studies have been done on ethionamide (ETH) PK in adult MDR-TB patients that are infected with HIV and those without HIV infection. Therefore, the objective of this current study was firstly, to find out ethionamide plasma concentration using the LC-MS method; secondly, to evaluate and compare the pharmacokinetics of ethionamide in MDR-TB patients infected with and without HIV infection; thirdly, to examine the effects of ARVs and kidney impairment on the PK of ethionamide and fourthly, to find out the consequence of sex and age on ETH PK parameters.enMultidrug-resistant tuberculosisHuman immunodeficiency virusMycobacterium tuberculosisAntiretroviral agentsEthionamidePharmacokineticsPlasma concentrationsLiquid chromatographyMass spectrometryThesisUniversity of the Western Cape