Egunlusi, A.O.Malan, S.F.Joubert, J.2021-09-072021-09-072020Egunlusi, Ayodeji & Malan, Sarel & Joubert, Jacques. (2020). Synthesis of 4-oxatricyclo[5.2.1.02,6]dec-8-ene-3,5-dione derivatives as lead scaffolds for neuroprotective agents. 10.24820/ark.5550190.p011.302.1551-7012http://hdl.handle.net/10566/6624Neurodegenerative disorders are characterised by progressive loss of neuronal functions. Of the proposed mechanisms, excitotoxicity, mediated by prolonged glutamate activation and calcium overload, is prominent. NGP1-01, a polycyclic cage amine, and tricyclo[6.2.1.02,7]undec-9-ene-3,6-dione have been shown to display calcium-modulating properties. In this study, we synthesised structurally-related 4-oxatricyclo[5.2.1.02,6]dec-8-ene-3,5-dione as the base scaffold, and incorporated various functional moieties through aminolysis, to afford a series of imide derivatives. All final compounds were obtained in yields between 47-97% and their structures were confirmed by NMR, IR and MS. These structurally-related derivatives could potentially act as neuroprotective agents. Additionally, their synthetic versatilities could make them precursors, as lead compounds, to potential pharmacologically-active agents.en4-Oxatricyclo[5.2.1.02,6]dec-8-ene-3,5-dioneCycloaddition reactionsAminolysisNorbornenesNorbornene scaffoldsNeurodegenerative disordersArticle