Igumbor, EMouton, J.PJobanputra, N2021-05-112021-05-112021Igumbor, E. et al. (2021). Adult medical emergency unit presentations due to adverse drug reactions in a setting of high HIV prevalence. African Journal of Emergency Medicine ,11(1), 46-522211-419X10.1016/j.afjem.2020.10.010http://hdl.handle.net/10566/6145South Africa has the world's largest antiretroviral treatment programme, which may contribute to the adverse drug reaction (ADR) burden. We aimed to determine the proportion of adult non-trauma emergency unit (EU) presentations attributable to ADRs and to characterise ADR-related EU presentations, stratified according to HIV status, to determine the contribution of drugs used in management of HIV and its complications to ADR-related EU presentations, and identify factors associated with ADR-related EU presentation. Methods: We conducted a retrospective folder review on a random 1.7% sample of presentations over a 12-month period in 2014/2015 to the EUs of two hospitals in Cape Town, South Africa. We identified potential ADRs with the help of a trigger tool. A multidisciplinary panel assessed potential ADRs for causality, severity, and preventability.enAdverse drug reactionEmergency departmentHIVPrevalenceSouth AfricaArticle