Joubert, Jacques2022-12-052022-12-052019Al-Wahaibi, L.H., Joubert, J., Blacque, O. et al. Crystal structure, Hirshfeld surface analysis and DFT studies of 5-(adamantan-1-yl)-3-[(4-chlorobenzyl)sulfanyl]-4-methyl-4H-1,2,4-triazole, a potential 11β-HSD1 inhibitor. Sci Rep 9, 19745 (2019). https://doi.org/10.1038/s41598-019-56331-zDOI: 10.1038/s41598-019-56331-zhttp://hdl.handle.net/10566/82275-(Adamantan-1-yl)-3-[(4-chlorobenzyl)sulfanyl]-4-methyl-4H-1,2,4-triazole (4) was identified as a potential 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitor and this paper describes the in-depth structural analysis thereof. Compound 4 was synthesized in a 92% yield and its 3D-structure confirmed by single-crystal X-ray diffraction.en-UScrystal X-ray11β-hydroxysteroid dehydrogenaseadamantyl moietymoleculesdrugsArticle