Pugh, David J.R.Mulaudzi, TakalaniMagister Scientiae - MScFaculty of Science2014-02-102024-05-092007/12/072007/12/072014-02-102024-05-092007https://hdl.handle.net/10566/13265Magister Scientiae - MScRetinoblastoma binding prot ein 6 (RBBP6) is a 250 kDa human splicing-associated protein that is also known to interact with tumour suppresso r proteins p53 and pRb and to mediate ubiquitination of p53 via its intera ction with Hdm2. RBBP6 is highly up regulated in oesophageal cancer, and has been shown to be a promising target for immunotherapy against the disease. RBBP6 is also known to play a role in mRNA splicing, cell cycle control and apoptosis.en15N-HSQC1H-113Cd-HSQCCadmium ionCoordinationExpressionRINGSpectroscopyZinc ionThesisUniversity of the Western Cape