Joubert, JacquesMalan, SarelEgieyeh, SamuelPokomi, Rostand Fankam2021-03-092024-10-292021-03-092024-10-292020https://hdl.handle.net/10566/16352Magister Pharmaceuticae - MPharmMalaria is an infectious disease which continues to kill more than one million people every year and the African continent accounts for most of the malaria death worldwide. New classes of medicine to combat malaria are urgently needed due to the surge in resistance of the Plasmodium falciparum (the parasite that causes malaria in humans) to existing antimalarial drugs. One approach to circumvent the problem of P. falciparum resistance to antimalarial drugs could be the discovery of novel compounds with unique scaffolds and possibly new mechanisms of action. Natural products (NP) provide a wide diversity of compounds with unique scaffolds, as such, a library of virtual compounds (VC) designed from natural products with antiplasmodial activities (NAA) can be a worthy starting point.enMalariaPlasmodium falciparumChloroquine resistanceDrug resistanceCheminformaticsUniversity of the Western Cape