Zhaku, VegimAgarwal, AshokHenkel, Ralf2021-06-212021-06-212021Zhaku, V., Agarwal, A., & Henkel, R. (2021). Male infertility, oxidative stress and antioxidants. in IntechOpen(Eds), Vitamin E in Health and Disease - Interactions, Diseases and Health Aspects [Working Title] (pp1-28). London: IntechOpen10.5772/intechopen.98204http://hdl.handle.net/10566/6312Within the male reproductive system, oxidative stress (OS) has been identified as prevailing etiology of male infertility. The effects of reactive oxygen species (ROS) on male fertility depend on the dimensions, “modus operandi” of the ROS and the oxido-reduction potential (ORP) of the male reproductive tract. Hereupon, for an adequate response to OS, the cells of our body are endowed with a wellsophisticated system of defense in order to be protected. Various antioxidant enzymes and small molecular free radical scavengers, maintain the delicate balance between oxidants and reductants (antioxidants), crucial to cellular function and fertility. Therapeutic use of antioxidants is an optimal and coherent option in terms of mitigating OS and improving semen parameters. Therefore, recognizing and managing OS through either decreasing ROS levels or by increasing antioxidant force, appear to be a requesting approach in the management of male infertility. However, a clear defined attitude of the experts about the clinical efficacy of antioxidant therapy is still deprived.enMale infertilityReactive oxygen speciesOxidative stressAntioxidantsSperm parametersBook chapter