Ebrahim, NaushaadUebel, R.A.2016-06-142016-06-142011Ebrahim, N. and Uebel, R.A. (2011). Direct inhibition of cyclooxygenase-2 enzyme by an extract of Harpagophytum procumbens, harpagoside and harpagide. African Journal of Pharmacy and Pharmacology, 5(20): 2209-22121996-0816http://hdl.handle.net/10566/2326A methanolic extract of Harpagophytum procumbens as well as harpagoside and harpagide were tested as direct inhibitors of cyclooxygenase-2 enzyme (COX-2). The H. procumbens extract demonstrated direct inhibition (68%) of COX-2 enzyme. The concentration of harpagoside and harpagide equivalent to that found in the extract (3 and 1% respectively) contributed 1.5 and 13% to this inhibition. Results indicated direct COX-2 enzyme inhibition by the H. procumbens extract due to possible synergistic activity of active components in the extract, which include harpagide and harpagoside.enAcademic Journals strongly supports the Open Access initiative. Abstracts and full texts of all articles published by Academic Journals are freely accessible to everyone immediately after publication.PharmacyPharmacologyHarpagophytum procumbensHarpagosideHarpagideCylcooxygenase-2Devils claw (Harpagophytum procumbens)Medicinal plantsArticle