Ebrahim, NaushaadUebel, R.A.2016-06-142016-06-142011Ebrahim, N. and Uebel, R.A. (2011). Direct inhibition of cyclooxygenase-2 enzyme by an extract of Harpagophytum procumbens, harpagoside and harpagide. African Journal of Pharmacy and Pharmacology, 5(20): 2209-22121996-0816http://hdl.handle.net/10566/2326A methanolic extract of Harpagophytum procumbens as well as harpagoside and harpagide were tested as direct inhibitors of cyclooxygenase-2 enzyme (COX-2). The H. procumbens extract demonstrated direct inhibition (68%) of COX-2 enzyme. The concentration of harpagoside and harpagide equivalent to that found in the extract (3 and 1% respectively) contributed 1.5 and 13% to this inhibition. Results indicated direct COX-2 enzyme inhibition by the H. procumbens extract due to possible synergistic activity of active components in the extract, which include harpagide and harpagoside.enPharmacyPharmacologyHarpagophytum procumbensHarpagosideHarpagideCylcooxygenase-2Devils claw (Harpagophytum procumbens)Medicinal plantsArticle