Kirby-McCullough, BronwynKing, Maria Catharina2021-08-232024-05-092021-08-232024-05-092021https://hdl.handle.net/10566/13563Philosophiae Doctor - PhDActinobacteria, a Gram-positive phylum of bacteria found in both terrestrial and aquatic environments, are well-known producers of antibiotics and other bioactive compounds. The isolation of actinobacteria from unique environments has resulted in the discovery of new antibiotic compounds that can be used by the pharmaceutical industry. In this study, the fynbos biome was identified as one of these unique habitats due to its rich plant diversity that hosts over 8500 different plant species, including many medicinal plants. In this study two medicinal plants from the fynbos biome were identified as unique environments for the discovery of bioactive actinobacteria, Aloe ferox (Cape aloe) and Sutherlandia frutescens (cancer bush).enActinobacteriaAntibacterialBioactive compoundsGenetic potentialGenome miningMedicinal plantsUniversity of Western Cape