Egunlusi, AMalan, SOmoruyi, S2021-09-012021-09-012020Egunlusi, A.O.; Malan, S.F.; Omoruyi, S.I.; Ekpo, O.E.; Joubert, J. 4-Oxatricyclo[5.2.1.02,6]dec-8-ene-3,5-dione Derivatives as NMDA Receptor- and VGCC Blockers with Neuroprotective Potential. Molecules 2020, 25, 4552. https://doi.org/10.3390/molecules251945521420-3049http://hdl.handle.net/10566/6590The impact of excitotoxicity mediated by N-methyl-D-aspartate (NMDA) receptor overactivation and voltage gated calcium channel (VGCC) depolarization is prominent among the postulated processes involved in the development of neurodegenerative disorders. NGP1-01, a polycyclic amine, has been shown to be neuroprotective through modulation of the NMDA receptor and VGCC, and attenuation of MPP+-induced neurotoxicity. Recently, we reported on the calcium modulating effects of tricycloundecene derivatives, structurally similar to NGP1-01, on the NMDA receptor and VGCC of synaptoneurosomes.enNeurodegenerative disorders4-oxatricyclo[5.2.1.02,6]dec-8-ene-3,5-dioneCytotoxicityNeuroprotectionNMDA receptorArticle