Poka, Madan Sai2024-11-072024-11-072024https://hdl.handle.net/10566/18967Poor aqueous solubility is a major concern for most new chemical entities (NCEs) developed for oral drug delivery as well as for almost 70% of registered and already marketed drugs. Solid-state alterations such as solid dispersions (SDs), co-amorphous and co-crystal systems have taken the lead over the past two decades, in an effort to address the challenge of poor drug solubility. One of the common factors amongst these techniques, that play a significant role in solubility enhancement, is the type of carrier or co-former used. Low molecular weight excipients such as amino acids, citric acid and a few sugars were studied as potential co-formers. However, the efforts made in identifying new low molecular weight excipients were modest. Given their low molecular weight, safety, hydrophilic nature and having high hydrogen bonding propensity makes polyols an interesting option to be explored as carriers.enSolid dispersionssolubility enhancementincreased dissolution ratemembrane permeationisoniazidThesis