Mugabo, PierreAbaniwonda, Ibukunoluwa Mercy2014-10-232024-05-152014-10-232024-05-152012https://hdl.handle.net/10566/15211Magister Pharmaceuticae - MPharmThe aim of the study was to determine firstly, kanamycin plasma concentrations using liquid chromatography coupled with mass spectrometry (LC/MS); secondly, to investigate the PK parameters of kanamycin in patients infected with MDR-TB and in patients co-infected with MDR-TB and HIV; thirdly, to assess the influence of HIV infection and renal impairment on the PK of kanamycin and fourthly, to find out whether there is any interaction between antiretroviral drugs and kanamycin.enMultidrug-resistant tuberculosisHIVLiquid chromatographyMass spectrometryPharmacokineticsPlasma concentrationsKanamycinDetermination of kanamycin plasma concentrations using LC/MS and pharmacokinetics of kanamycin in patients with multidrug-resistant tuberculosis and in patients with multidrug-resistant tuberculosis co-infected with HIVThesisUniversity of the Western Cape