Titinchi, SalamSalubi, Christiana Abimbola2022-08-122024-05-132024-05-132022https://hdl.handle.net/10566/14700Philosophiae Doctor - PhDThe main purpose of this study was to synthesize biguanide compounds with potential as antidiabetic drugs. All biguanide compounds possess antidiabetic properties by decreasing the blood glucose level. Hence, we embarked on the synthesis of a series of biguanides in a threestep reaction which involves synthesis of a Schiff base, reduction of the Schiff base to a secondary amine using sodium borohydride and lastly formation of substituted biguanide derivatives with amines (primary or secondary) and dicyandiamide.enDicyandiamideBiguanideDiabetesAntidiabetic drugsChemistryUniversity of the Western Cape