Sharma, Jyoti RajanSibuyi, Nicole Remaliah SamanthaFadaka, Adewale Oluwaseun2023-04-202023-04-202023Sharma, J. R. et al. (2023). Anticancer and drug-sensitizing activities of gold nanoparticles synthesized from cyclopia genistoides (honeybush) extracts. Applied Sciences, 13(6), 3973. https://doi.org/10.3390/app130639732076-3417https://doi.org/10.3390/app13063973http://hdl.handle.net/10566/8842Synthesis of gold nanoparticles (AuNPs) using phytochemicals has become tremendously prominent in biomedical applications because of its enhanced bioactivity and biocompatibility. In this study, water extracts from the leaves of Cyclopia genistoides (C. genistoides), commonly known as honeybush (HB), were used to synthesize honeybush gold nanoparticles (HB-AuNPs). The HB water extracts (HBE) served as both reducing and capping agents in the synthesis of HB-AuNPs. The HB-AuNPs were characterized by UV–Vis spectrophotometry, dynamic light scattering (DLS), and transmission electron microscopy (TEM). The cytotoxicity and apoptotic effects of the HBE and HB-AuNPs, alone and in combination with doxorubicin (Dox), were examined against various human cell lines. Spherical-shaped HB-AuNPs with a hydrodynamic diameter range of 63 to 121 nm were produced.enGold nanoparticlesBiotechnologyGreen synthesisMedicinal plantsPhytotherapyArticle