Investigation of the Stress-Induced Nuclear Localisation of Retinoblastoma Binding Protein 6 (Rbbp6) and its Role in Ubiquitination Of Y-Box Binding Protein-1 (Yb-1)

Pugh, J. R.Mahomedy, Tephney Gladness2018-04-092024-05-092018-04-092024-05-092017https://hdl.handle.net/10566/13437Magister Scientiae - MSc (Biotechnology)Retinoblastoma Binding Protein 6 (RBBP6) is a 200 kDa RING finger-containing human protein known to serve as an E3 ubiquitin ligase, and to play a role in ubiquitination and suppression of the tumour suppressor p53. It also regulates the stability of mRNA transcripts by modulating 3'-polyadenylation.enInvestigation of the Stress-Induced Nuclear Localisation of Retinoblastoma Binding Protein 6 (Rbbp6) and its Role in Ubiquitination Of Y-Box Binding Protein-1 (Yb-1)University of the Western Cape