Amabeoku, George J.Bamuamba, Kapinga2023-03-072023-03-072010Amabeoku, G. J., & Bamuamba, K. (2010). Evaluation of the effects of Olea europaea L. subsp. africana (Mill.) P.S. Green (Oleaceae) leaf methanol extract against castor oil-induced diarrhoea in mice. Journal of Pharmacy and Pharmacology, 62 (3) ,368-373. https://doi.org/10.1211/jpp.62.03.00122042-7158https://doi.org/10.1211/jpp.62.03.0012http://hdl.handle.net/10566/8543Olea europaea L. subsp. africana (Mill.) P.S. Green is widely used in South Africa by traditional medicine practitioners to treat diarrhoea. However, little is known scientifically about this South African species in the treatment of diarrhoea. The main aim of the study therefore was to investigate the antidiarrhoeal effect of the leaf methanol extract of the plant species in mice. The antidiarrhoeal activity of the leaf methanol extract of O. europaea subsp. africana was studied using a castor oil-induced diarrhoeal test. The antipropulsive activity of the plant extract was also investigated using the charcoal meal transit test. Standard methods were used to investigate the acute toxicity and effect of O. europaea subsp. africana on castor oil-induced intraluminal fluid accumulation.enAcute toxicityAntidiarrhoealOleaceaePharmacologyDiarrhoeaArticle