Motswainyana, William M.Onani, Martin O.Madiehe, Abram M.2014-03-312014-03-312012Motswainyana, W.M., Onani, M.O. & Madiehe, A.M. (2012). Bis(ferrocenylimine)palladium(II) and platinum(II) complexes: synthesis, molecular structures and evaluation as antitumor agents. Polyhedron 41: 44 - 510277-5387http://hdl.handle.net/10566/1066Compounds (ferrocenyl-2-furylmethyl)imine (L1), (ferrocenyl-2-thiophenemethyl)imine (L2) and (ferrocenyl-2-thiopheneethyl)imine (L3) were synthesized by condensation reactions and obtained in very good yields. Reactions of L1 – L3 with 0.5 equiv of either PdCl2(cod), PdClMe(cod) or K2[PtCl4] gave the new corresponding trans bis(ferrocenylimine)palladium(II) and platinum(II) complexes 1 – 9. The compounds were characterized by elemental analysis, IR, 1H and 13C NMR spectroscopy. The molecular structures of 3 and 6 were determined by single crystal X-ray diffraction analysis. Both structures crystallize in monoclinic P21/n space system. The coordination geometry around the palladium atom in complexes 3 and 6 exhibits a square planar geometry at the palladium atom. Complexes 1, 7 and 9 were evaluated for their cytotoxic activities against human breast (MCF-7) and human ovarian (A2780) cancer cell lines, and they exhibited low cytotoxic activities but comparable to that of cisplatin.enThis is the author postprint version of an article by Elsevier. The file may be freely used, provided that acknowledgement of the source is given.FerrocenyliminePalladiumPlatinumMolecular structuresCytotoxicityCancerCisplatinArticle