Crutchley, Rustin D.Keuler, Nicole2023-06-052023-06-052022Crutchley, R. D., & Keuler, N. (2022). Sub-analysis of cyp-guides data: Assessing the prevalence and impact of drug-gene interactions in an ethnically diverse cohort of depressed individuals. Frontiers in Pharmacology, 13, 884213. 10.3389/fphar.2022.8842131663-9812https://doi.org/10.3389/fphar.2022.884213http://hdl.handle.net/10566/9007Minority groups are underrepresented in pharmacogenomics (PGx) research. Recent sub-analysis of CYP-GUIDES showed reduced length of stay (LOS) in depressed patients with CYP2D6 sub-functional status. Our primary objective was to determine whether PGx guided (G) versus standard treatment (S) influenced LOS among different race/ethnic groups. Secondary objectives included prevalence of drug-gene interactions (DGIs) and readmission rates (RAR). Retrospective sub-analysis of CYP-GUIDES data comprising CYP2D6 phenotypes was reclassified using standardized CYP2D6 genotype to phenotype recommendations from the Clinical Pharmacogenetics Implementation Consortium (CPIC) and Dutch Pharmacogenetics Working Group (DPWG).enPharmaceuticPharmacologyEthnicityRaceDepressionArticle