Kinyili, MusyokaMunyakazi, Justin B.Mukhtar, Abdulaziz Y. A.2023-06-142023-06-142023Kinyili, M. et al. (2023). Modeling the impact of combined use of Covid Alert SA app and vaccination to curb Covid-19 infections in South Africa. PLoS ONE, 18(2), e0264863. https://doi.org/10.1371/journal. pone.02648631932-6203https://doi.org/10.1371/journal.pone.0264863http://hdl.handle.net/10566/9084The unanticipated continued deep-rooted trend of the Severe Acute Respiratory Syndrome Corona-virus-2 the originator pathogen of the COVID-19 persists posing concurrent anxiety globally. More effort is affixed in the scientific arena via continuous investigations in a prolific effort to understand the transmission dynamics and control measures in eradication of the epidemic. Both pharmaceutical and non-pharmaceutical containment measure protocols have been assimilated in this effort. In this study, we develop a modified SEIR deterministic model that factors in alternative-amalgamation of use of COVID Alert SA app and vaccination against the COVID-19 to the Republic of South Africa’s general public in an endeavor to discontinue the chain of spread for the pandemic. We analyze the key properties of the model not limited to positivity, boundedness, and stability.enPublic healthCovid-19South AfricaStatistics studiesVaccine developmentArticle